"Who is Amanda Knox?" said attorney Carlo Pacelli. "Is she the mild-looking, fresh-faced person you see here, or the one devoted to lust, drugs and alcohol that emerges from the court documents?"
Knox and her former boyfriend Raffaele Sollecito were convicted of sexually assaulting and murdering 21-year-old Meredith Kercher in 2007. Prosecutors are asking a judge to increase her 26-year sentence to life in prison.
Gruesome photos of Kercher's semi-naked, bloodied body were shown in open court. Silence fell in the courtroom as the images appeared on a screen. Knox mostly seemed to keep her head down.
Knox and Sollecito insist they spent the night at his house the night of the murder.
Curt Knox insisted his daughter was always serious and that "you just don't go abroad and freak out in a short period of time."
"Does he accomplish proving anything by name-calling?" Knox's father added.
The defense begins on Tuesday, and Knox will have a final chance to address the court.
The Associated Press contributed to this report.