The driver crashed through a concrete support in Fort Lauderdale early Wednesday morning on the ramp leading from a state road to Interstate 95.
Two people were inside the truck, which bears a sign for a Miami bakery. One of them was rescued, and the other was pinned inside and died of his injuries.
A tow truck ended up pulling the bakery truck back onto the freeway. It's unclear what caused the crash.
The Associated Press contributed to this report.