That brings the animated film's total revenue to over $140 million in just 10 days, beating out this weekend's newest flicks.
In second place, the action comedy "The Heat" brought in $40 million in its debut weekend.
According to studio estimates Sunday, Brad Pitt's "World War Z" took the No. 3 spot with nearly $30 million.
Channing Tatum and Jamie Foxx's film "White House Down" finished in fourth place with $25.7 million. The film features Tatum as a wannabe Secret Service agent and Foxx as the President of the United States of America.
"Man of Steel" rounded out the top five with just under $21 million.
1. "Monsters University," $46.1 million ($44.2 million international).
2. "The Heat," $40 million.
3. "World War Z," $29.8 million ($70.1 million international).
4. "White House Down," $25.7 million ($6.8 million international.)
5. "Man of Steel," $20.8 million ($52.2 million international).
6. "This Is the End," $8.7 million.
7. "Now You See Me," $5.5 million ($5 million international).
8. "Fast & Furious 6," $2.4 million ($6.1 million international).
9. "Star Trek: Into Darkness," $2 million ($2 million international).
10. "The Internship," $1.4 million ($3.6 million international).
The Associated Press contributed to this report.
