The show follows a former starlet who is roped into solving crimes with her former TV show co-star of a popular 90s crime-solving series.
Holly, Spelling's character, opens a detective agency and persuades Charlie, Garth's character, now a suburban mom, to help.
Spelling, Garth and Maggie Malina, of "Single Laides," will serve as executive producers of the show. The pilot was written by Shepard Boucher, of "Men at Work."
"Mystery Girls" is scheduled to shoot in November.