The incident occurred on the 1200 block of Papeete Street around 2:45 a.m., and began when a fight broke out.
Police believe the suspect was beaten up, left the party, came back with a gun and started shooting.
One of the four victims was listed in critical condition. The remaining three victims are in stable condition.
The suspect was last seen fleeing in a black BMW.
Detectives believe the shooting was gang-related.