Authorities say the victim was driving westbound on the 210 in his black Mitsubishi Eclipse shortly before 1 a.m. when a driver in another vehicle opened fire. It appeared the victim was shot through the driver's side window.
The Eclipse came to a stop on an embankment on the Roxford Street off-ramp.
The victim was identified as 34-year-old Pacoima resident Sergio Sanchez.
The exact reason for the shooting remains unknown, but detectives believe the incident involved road rage. LAPD Lt. Paul Vernon said the victim lived locally and was likely coming from or going to work.
Investigators said this was a "one-way" shooting: Sanchez did not have a gun. Authorities also said the victim did not have any gang or criminal ties.
Following the shooting, the westbound 210 Freeway was shut down just north of the 118 Freeway as officers scoured the roads for evidence. All roads were reopened at around 4:30 a.m.
Detectives said they will look into other reports of shots fired, which came in around 11 p.m. near Fenton and Tyler streets, about one mile from the car shooting scene. Responding LAPD officers did not find any witnesses or victims in that case. Vernon said given the two-hour gap between the incidents, it's unlikely the cases are related.
If you have any information about this case, you're urged to contact LAPD at (877) LAPD-24-7.