Click in the Eyewitness News story window above to watch Miriam Hernandez's report from the scene.
Authorities say they originally tried to pull the suspect over in San Bernardino for erratic driving, but he refused to pull over. He was going the wrong way on the 215 Freeway.
"The driver at that time was attempting to grab for something under his seat and refused to stop for the deputies," said Jodi Miller from the San Bernardino County Sheriff's Department.
Deputies attempted one or two pit maneuvers, but the driver just became more aggressive.
"[He] rammed one of our Rancho Cucamonga units head on with our deputy in it, and an officer involved shooting then occurred," said Miller.
The chase finally ended on Mountain Avenue near the 210 Freeway when the driver slammed head-on into a sheriff's patrol car and deputies opened fire.
As many as eight pursuing units were struck before the driver crashed into a sound wall. He was killed either at impact when he hit the wall or by gunfire from the deputies trying to stop him.
Deputies are relieved innocent motorists were not hurt in the chase that went from San Bernardino to Rancho Cucamonga to Upland.
None of the deputies were seriously injured in the pursuit.
"We have a few of the deputies who have some complain of pain," said Miller. "Obviously we had some air bags deploying on them and such. But yes, thank you very much, they're all going to be just fine."
The driver has not yet been identified. He's described as a Hispanic male in his 30s.
Mountain Avenue remains closed as the investigation continues.