The film, starring Seth Rogen as a playboy-turned-crimefighter took down last week's top earner, the Western "True Grit."
Universal's "The Dilemma," starring Vince Vaughn and Kevin James opened the No. 2 spot, raking in $17.4 million.
Potential Oscar contenders "True Grit," "The King's Speech" and "Black Swan" respectively followed behind "Green Hornet" and "The Dilemma."
1. "The Green Hornet," $34 million.
2. "The Dilemma," $17.4 million.
3. "True Grit," $11.2 million.
4. "The King's Speech," $9 million.
5. "Black Swan," $8.1 million.
6. "Little Fockers," $7.1 million.
7. "Tron: Legacy," $5.6 million.
8. "Yogi Bear," $5.3 million.
9. "The Fighter," $5.1 million.
10. "Season of the Witch," $4.5 million.
The Associated Press contributed to this report.