Authorities responded to the scene near the corner of Towne and East San Bernardino avenues at about 8:30 a.m. One person in the car was declared dead at the scene, and a second person in the car was taken to a local hospital in critical condition.
Other than the driver, no one was on the tour bus, and the driver was not injured.
Witnesses said the car may have run a red light before colliding with the bus.
Pomona police are investigating the accident.