Firefighters responded to the blaze at about 4:30 p.m. The fire was knocked out in 23 minutes. Officials say the woman's body was found during a search of the trailer.
Two officers had smoke inhalation. They were hospitalized and released overnight.
The name of the woman killed in the fire has not been released.
The cause of the fire remains under investigation. Firefighters said they found packrat conditions inside the mobile home.