The jurors viewed home videos of the three children and saw how Michael Jackson raised them.
Prince testified that his life will never be the same without his father.
All three Jackson children are suing tour promoter AEG for $50 million each in general damages. The claim alleges that AEG hired Dr. Conrad Murray and failed to supervise him.
The 16-year-old told the jury that he saw his father angry at AEG officials, who were partnering with him to stage his comeback tour. Prince said his father would cry sometimes.
"'They're going to kill me. They're going to kill me,'" Prince said he heard his father say.
The teenager also told jurors about his father's secretiveness when Dr. Murray came nightly to the house. The singer's bedroom was always locked.
AEG claims that the tour producers did not know of Murray's treatments with propofol. The company denies hiring Jackson and says that Murray's relationship with Jackson went back to 2006.
In court, the defense played an earlier statement from Prince.
"Did you ever see your father pay Dr. Conrad Murray?" AEG defense attorney Marvin S. Putnam asked Prince in the videotaped deposition.
"I've seen him a couple of times," Prince responded.
"Did he pay him in cash?" Putnam asked.
"He did only a couple of times in the house but mostly in Vegas," Prince said.
"We shouldn't minimize how tragic the loss really is for them," defense attorney Marvin Putnam said Wednesday. "I think what it doesn't go to remotely is why their father passed."
Other members of the Jackson family are expected to testify. The attorney for the plaintiff says Jackson's daughter, Paris, could take the witness stand if she gets a clearance from her doctor.