The crash occurred on the 5700 block of Passons Boulevard around 12:53 a.m.
According to authorities, the driver of the patrol car observed an approaching vehicle as he approached the intersection of Mines Avenue. The deputy allegedly swerved to avoid a collision but lost control.
Two deputies were transported to a trauma center with serious injuries. They are now listed in stable condition. The other two deputies were transported to a local hospital with minor injuries and have since been released.
Authorities said the deputies were responding to an assistance request of a deputy in a fight.
No other information was released. The investigation is ongoing.