The accident happened around 6:45 a.m. Sunday on the westbound side of the freeway at Durfee Avenue.
According to the California Highway Patrol, the woman was driving recklessly before the accident. Officers say the Ford truck hit the center divider, overturned, and the woman was ejected and killed.
The woman was the only person in the truck. Her name has not been released.
The CHP says all but one lane of the westbound freeway were closed due to the crash. All lanes were back open just before 9 a.m.