The latest robbery happened around 8 p.m. Monday on the 13900 block of North Harbor Boulevard.
Police say the suspects got away with $800 after threatening an employee.
Last Friday night, there was a similar robbery at Angel's Smoke Shop at the corner of Westminster Boulevard and Harper Street. No one was hurt in either robbery.
Both suspects are described as Hispanic men in their 20s.
The first suspect was described as being about 5 feet 6 inches to 5 feet 9 inches tall, weighing about 250 pounds, with short, black hair. He was described as having a heavy build and wearing a scarf or bandana to cover his face.
The second suspect was described as being about 5 feet 7 inches to 5 feet 9 inches tall and weighing about 140 pounds. He was described as having a thin build and also wearing a scarf or bandana to cover his face.
If you have any information about this case, you're urged to call Orange County Crime Stoppers at (855) TIP-OCCS of (855) 847-6227.