The burglary occurred Feb. 24 on the 27900 block of Tyler Lane. The homeowner said the garage door may have been left open at the time of the theft.
The "Karma" wheelchair has a custom candy-apple red paint job with ghost flames running along the bars of the chair.
It was specially-made for the homeowner's disabled son. His black backpack, which was attached to the wheelchair, was also taken.
Anyone with information was asked to call Los Angeles Crime Stoppers at (800) 222-TIPS.