Egypt's prosecutor-general announced that the 83-year-old leader and his two sons are also charged with abusing power to amass wealth, enriching associates and accepting bribes.
Mubarak stepped down Feb. 11 and transferred power to Egypt's military after an 18-day uprising. At least 846 protesters were killed in the clashes.
A trial date has not yet been set.
Putting Mubarak on trial is a key demand of many Egyptians who have rallied to demand the ousted leader and his aides face justice.
Mubarak has been in custody in a hospital in the Red Sea resort of Sharm el-Sheikh since last month. His two sons are in detention in a Cairo prison.
The Associated Press contributed to this story.