Perry, who scored a league-best 50 goals, the Sedins' NHL MVP party.
Scoring champion Daniel Sedin of the Vancouver Canucks was trying to complete an unprecedented MVP double dip after his twin brother and teammate Henrik took the honors last year.
Even Perry said he didn't expect to take home the trophy.
Perry's win capped the two-hour NHL Awards ceremony. Tampa Bay's Martin St. Louis, who won the Lady Byng Trophy for gentlemanly and excellent play, was the third MVP finalist.
The Associated Press contributed to this report.