The incident occurred on Alameda Street near the westbound 10 Freeway off-ramp around 2 a.m.
CHP responded to a pedestrian down call and found a body in the No. 2 lane of the off-ramp with no vehicle in sight.
The victim was pronounced dead at the scene. He was identified as a man in his early 30's.
No description of the fleeing vehicle was released.
The fatal crash closed Alameda Avenue and the off-ramp for a few hours, but both have since reopened.
The hit-and-run remains under investigation. Anyone with information was urged to contact CHP at (213) 744-2331.