According to the sheriff's department, detectives from the LASD's Special Victims Bureau served a search warrant at the star's Hollywood area home as part of the ongoing investigation.
Manson, whose legal name is Brian Hugh Warner, has been accused of sexual assault and physical abuse by more than 15 women.
The sheriff's department said in February that its detectives had begun investigating Manson over reports of domestic violence between 2009 and 2011 in West Hollywood, where he lived at the time.
The women involved were not identified, but several women have publicly alleged this year that they were physically, sexually and emotionally abused by Manson around the time of the incidents under investigation, and some have filed lawsuits.
Manson has denied the allegations.
One of his accusers is three-time Golden Globe nominee Evan Rachel Wood, Manson's former fiancee. She named him as her abuser for the first time in an Instagram post in February. Manson called Wood's statements "horrible distortions of reality."
In May, "Game of Thrones" actor Esmé Bianco sued Marilyn Manson in federal court, alleging sexual, physical and emotional abuse. Bianco says that Manson violated human trafficking law by bringing her to California from England for non-existent roles in music videos and movies.
Manson deprived Bianco of food and sleep, locked her in a bedroom, whipped her, gave her electric shocks and threatened to enter her room and rape her during the night, the lawsuit alleges.
Bianco's attorney said she also was interviewed by law enforcement.
And Manson's former assistant accused him of sexual assault, battery and harassment in her own lawsuit, saying he used "his position of power, celebrity and connections to exploit and victimize during her employment."
Manson emerged as a musical star in the mid-1990s, known as much for courting public controversy as for hit songs like "The Beautiful People" and hit album's like 1996's "Antichrist Superstar" and 1998's "Mechanical Animals."
MORE | Marilyn Manson under investigation by LA County Sheriff's Department for domestic violence allegations
The Associated Press contributed to this report.