Zoo keepers say there's no need to panic, since they believe the snake is contained in the zoo's Reptile House. The enclosure is separate from the animal exhibits and not accessible by the public.
The cobra hasn't been seen since it got out of its enclosure on Friday.
The Reptile House is shut down and zoo keepers say the deadly 20-inch-long snake will probably come out of hiding when it gets hungry or thirsty. Snakes usually seek closed-in spaces and aren't comfortable in open areas.
Egyptian cobras kill close to 50,000 people a year in third world countries. The cobra's venom is said to be so poisonous that it can kill an elephant in three hours and a human in 15 minutes.
This certainly wouldn't be the first time a zoo animal made a run for it.
In 2003, the U.S. Department of Agriculture filed a complaint in court after 35 animals in five years made their way out of their exhibits at the Los Angeles Zoo.
In 2008, a chimpanzee at a zoo in Japan was so eager to get his freedom that he fought for it, snatching a tranquilizer gun from a guard's hands.
ABC News contributed to this report.