The incident happened around 7:30 p.m. on the 11300 block of Pearl Street.
Officials said the victim, a man in his 30s, died at the scene.
"Witnesses heard about six or seven gunshots, looked outside and saw the victim collapse from apparent gunshot wounds," said Det. John Skaggs of the Los Angeles Police Department.
Police said the gunman fled on foot.
Anyone with information was asked to contact police at (877) LAPD-24-7.
DEVELOPING... We will add more details to this report as they become available.