The crash happened just after 11:45 p.m. Saturday on Ventura Boulevard just east of Fairway Avenue.
Police said the victim was crossing the street when a white Mercedes Benz CLS hit him, carried him about 100 yards and took off. It's not known if the man was in a crosswalk.
The victim was pronounced dead at the scene. His name has not been released.
Police said the car sustained major damage in the front and possibly a smashed windshield. Officers said the car had black paper plates with the word "Encino" written in yellow.
Anyone with information was asked to call the Los Angeles Police Department at (877) 527-3247.