Stores selling the tickets are expected to be busy with lotto hopefuls lining up for a chance to win.
"When it goes beyond $100 million, then I get in it, but I'm not a consistent player," said Edwin Medina of Perris. "You never know, you have to be in it to win it."
Last week's drawing had 31 tickets with five matching numbers, but none of them had the Mega number, meaning no one took home the jackpot.
Mega Millions is played in 41 states. Tuesday night's drawing will be the 16th since the last winning jackpot ticket was sold.
The chance of winning the jackpot is one in almost 176 million.