Mandatory evacuations have been ordered for the Dos Vientos area and for Cal State University Channels Islands.
The fire started around 6:45 a.m. near the Camarillo Springs Road exit and was burning quickly in steep terrain.
Officials said 200 firefighters were at the scene and additional crews were expected to be called in to fight the flames from the air and the ground.
Two right lanes on the southbound 101 Freeway were shut down near Camarillo Springs Road. Major traffic was reported in the area.
Residents who need more information can call Ventura County fire officials at (805) 388-4276.
DEVELOPING: We will add more details to this report as they become available.