Scientists followed more than 80,000 women ages 54 to 79.
They found women with a history of depression had a 29-percent greater risk of suffering a stroke. And women who took antidepressants face a 39-percent higher risk.
Researchers are not sure the medication is the cause.
Scientists say this should not lead women to stop taking antidepressants.
The study is in Stroke: Journal of the American Heart Association.